Amanda Knox's innocence on murdering Meredith Kercher is the prevailing question of many investigators, as far as the list of high-profile cases is concerned. This case, evidently, is unsolvable in just a set of evidence. 

There are evidence pointing that Knox and her former boyfriend Raffaele Sollecito faked roommate Filomena's room by shattering the windows and refashioning the scene for it to be staged as if a burglar entered - leading to Kercher's nightmare.

On the contrary, Rudy Guede had already admitted sexual assaults and he was already convicted with the murder that led him to serve behind bars on his life sentencing. On the side of the former couple, why is this case undone?

Firstly, Amanda Knox's DNA was found to be mixed with Kercher's. On several blood stains found on the rag, bathroom (which Kercher and Knox shared), light-bulb switch and floor, all shows the evidence of Knox's presence on the middle of November 1 and 2-crime scene in Perugia, Italy.

Thereafter the investigations, forensic experts namely, Dr. Renato Biondo, Dr. Patrizia Stefanoni and Prof. Franccesca Torricelli disclosed that Kercher's DNA was found on a kitchen knife found on Raffaele's loft. The kitchen knife, which being held as primary evidence, was investigation due to an "investigative intuition".

On many occasions such as this, guesses, hypothesis and sample contamination could lead that evidence are questionable and unreliable.

The defense team proposed that the blood might be mixed with Kercher due to Knox's ability to excrete mentrual blood and wound's blood, which may have been from Knox's ear as it was just pierced.

In addition, the bra clasp metal, which was found days after the first set of evidences were tested, might also be contaminated; thus, leaving the contradicting statement that Amanda's DNA will always be visible under the microscopes as she lives there as well.

There are bunch of explanations that lead to Amanda Knox and Raffaele Sollecito's innocence. Simultaneously, evidences show their DNA samples that prosecutes them for a guilty verdict.

How will Italy's Highest Court of Cassation refocus all these, as it becomes next year's subject? Are they victims of mere theories or will the evidence dispatch them behind bars?